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NEOGEN treatment decreases the riks of developing skin cancer.

Actinic keratosis (AK) forms on the face, lips, back of neck, hands, and bald scalp following sun exposure over a period of time. It appears as a rough, dry, scaly patch or growth on the exposed skin. The blemishes are often elevated, rough in texture and resemble warts. Individuals with Actinic Keratosis usually have more than one blemish.

If it is left untreated, AKs may turn into squamous cell carcinoma. In some cases it may turn into basal cell carcinomas, the most common form of skin cancer, it is, therefore important that a dermatologist is consulted before any cancerous changes occur.

Causes and Risk Factors of Actinic Keratosis (AK); longterm sun exposure is the major cause of actinic keratosis. Sun damage to the skin is cumulative, so every period of sun exposure adds to the lifetime total. Another important cause of actinic keratosis is exposure to the ultraviolet radiation given off by tanning beds.

A further possible cause of actinic keratoses is extensive exposure to X-rays or certain industrial chemicals, like arsenic, coal tar, soot, pitch, creosote, shale oils, and petroleum products, such as mineral oil or motor oil.

The following individuals are also more vulnerable to actinic keratosis:

• Individuals whose immune defences are weakened by cancer chemotherapy, Aids, or organ transplantation

• People with fair skin, blonde or red hair, and blue, green, or grey eyes

• People with certain rare conditions that make the skin very sensitive to the sun's UV rays, such as albinism and xeroderma pigmentosum (XP), are also at higher risk.

Risk Factors Include individuals:

• Usually of the male gender

• A fair skin

• Light eye colour

• Who spend lots of time outdoors in the sun

• Who are organ transplant recipients

• High alcohol consumption

The signs and symptoms of an actinic keratosis include:

• Rough, dry or scaly patch of skin

• Blemishes may range in size from a tiny spot to as much as an 2,5cm

• Flat to slightly raised patch or bump on the top layer of skin

• In some cases it may have a hard, wart-like surface

• Colour varies between pink, red or brown, or flesh-coloured patches

• There may also be itching or burning of the affected areas

A medical practitioner (preferably a dermatologist) should be consulted when blemishes on the skin are noticed. He/she will:

• Conduct a full physical examination

• Obtain a biopsy to confirm the diagnosis

The following will assist in reducing the risk for actinic keratosis:

• Avoiding the midday sun.

• Apply an effective sunscreen (SPF30 or higher) regularly at least 20 minutes before going out

into the sun

• Pay special attention to the lips. Apply a lip balm that contains sunscreen (if available)

• Protect the skin with clothing, preferably with a good UPF value. Whenever possible wear:

▪ A wide-brimmed hat

▪ Long sleeves

▪ Long pants

• Avoid tanning beds or other indoor tanning devices

• Check the skin as often as recommended by a dermatologist

• One should contact a dermatologist right away if patches:

▪ Starts to itch or bleed

▪ Become noticeably thicker

▪ Remain after treatment

▪ Change in size, shape, or colour.

• Avoid alcohol or, at least, reduce alcohol consumption

Treatment may include:

NEOGEN Nitrogen gas derived skin regeneration treatment is an FDA approved treatment for AK lesions.

The CE marking approval of the NeoGen system as a medical device against the EU directive 93/42/EEC is limited to the following medical claims only.

The following are classified as medical conditions:

• Acne scars – treated as a poor prognostic indicator due to their appearance and permanency and therefore they are an indication for medical treatments including isotretinoin. To minimise the psychological effects such as social withdrawal, depression and anxiety.

• Actinic Keratosis – these can lead to more serious squamous cell carcinoma (SCC) if left untreated. Up to 40% of SCC’s begin as actinic keratoses. Failure to treat these pre-malignant lesions effectively at an early stage substantially increases the risk of more acute surgery with its associated morbidity and patient discomfort.

Additionally, the NeoGen System is intended for treatment of the following non-medical conditions:

• Facial rhytides (wrinkles)

• Non-facial rhytides (wrinkles)

• Superficial skin lesions including pigmented lesions, Seborrhoeic Keratosis and Viral papillomata

Skin Cancer Foundation

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